University of Colorado Boulder - Genetic Epidemiology Foundations 

Course Introduction

Module 1 Introduction: What is Genetic Epidemiology?

Origins of Genetic Epidemiology

Legacies of these Origins and Scientific Rigor

Liability and Threshold Models: Introduction

Testing and an Example

Genetic Regulation of Gene Expression

Introduction

Methods

Methods Continued and Extension

Pleiotropy

Glossary

References and Links

Module 1 Summative Assessment

Introduction to Population Genetics

Hardy-Weinberg Equilibrium Definition and Implications

HWE Testing and P-Values

HWE Testing Power, QQ Plots, and Multiple Tests

HW Departures and Population Structure

Genetic Drift I

Genetic Drift II

Population Structure I

Population Structure II

Inbreeding and Relatedness I

Inbreeding and Relatedness II

Inbreeding and Relatedness III

Linkage Disquilibrium I

Linkage Disquilibrium II

Linkage Disquilibrium III

Linkage Disquilibrium IV

Related Articles

Module 2 Summative Assessment

Population Structure

Definition of Population Structure and Brief Overview of Human History

Factors the Influence Population Structure and Genetic Drift

Natural Selection

Examples of Population Structure in Modern Humans

Pima Example

Statistical Methods I: Structured Association and Genomic Control

Statistical Methods II: Principal Components Analysis

Statistical Methods III: LD Score Regression

Statistical Methods IV: Principal Components

Statistical Methods V: Mixed Models

Statistical Methods VI: Admixture Mapping

Resources Part 1

Resources Part 2

Module 3 Summative Assessment

Basic Quality Control in Genetic Data

Motivation and Background

Introduction to Quality Control

QQplots: Part 1

QQplots: Part 2

Mendelian Inconsistency Checks

Population Structure: Part 1

Population Structure: Part 2

Genotype Imputation: Introduction

Genotype Imputation: The Details, Part 1

Genotype Imputation: The Details, Part 2

Optional Readings

Module 4 Summative Assessment

Population-Based Association Studies

Basic Measures: Part 1

Basic Measures: Part 2

Common Modeling Strategies: Part 1

Common Modeling Strategies: Part 2

Introduction to Multiple Testing: Part 1

Introduction to Multiple Testing: Part 2

Reproducibility: Part 1

Reproducibility: Part 2

Introduction to Genotype Imputation: Part 1

Introduction to Genotype Imputation: Part 2

Introduction to Meta-Analysis and Consortia: Part 1

Introduction to Meta-Analysis and Consortia: Part 2

Introduction to Meta-Analysis and Consortia: Part 3

Resources

Module 5 Summative Assessment

Family-Based Designs

Overview

Familial Clustering

Twin Studies

Other Designs

Classical Methods

Modern Methods

Basics Part 1

Basics Part 2

Recombination and Mapping

Parametric Methods

Model-Free Methods

Overview Part 1

Overview Part 2

Types of Methods

Overview

Linkage

Association

References and Software

Module 6 Summative Assessment