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University of Geneva - Classical papers in molecular genetics 

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  • Public/Government Institute

Classical papers in molecular genetics
 at 
Coursera 
Overview

Duration

28 hours

Total fee

Free

Mode of learning

Online

Official Website

Explore Free Course External Link Icon

Credential

Certificate

Classical papers in molecular genetics
Table of content
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Classical papers in molecular genetics
 at 
Coursera 
Highlights

  • Shareable Certificate Earn a Certificate upon completion
  • 100% online Start instantly and learn at your own schedule.
  • Flexible deadlines Reset deadlines in accordance to your schedule.
  • Approx. 28 hours to complete
  • English Subtitles: French, Portuguese (European), Russian, English, Spanish
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Classical papers in molecular genetics
 at 
Coursera 
Course details

More about this course
  • You have all heard about the DNA double helix and genes. Many of you know that mutations occur randomly, that the DNA sequence is read by successive groups of three bases (the codons), that many genes encode enzymes, and that gene expression can be regulated.
  • These concepts were proposed on the basis of astute genetic experiments, as well as often on biochemical results. The original articles were these concepts appeared are however not frequently part of the normal curriculum of biologists, biochemists and medical students.
  • This course proposes to read study and discuss a small selection of these classical papers, and to put these landmarks in their historical context. Most of the authors displayed interesting personal histories and many of their contributions go beyond not only the papers we will read but probably all their scientific papers.
  • Our understanding of the scientific process, of the philosophy underlying the process of scientific discovery, and on the integration of new concepts is not only important for the history of science but also for the mental development of creative science.
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Classical papers in molecular genetics
 at 
Coursera 
Curriculum

Session 1

Introduction

Part 1 - Perspective

Part 2

Part 3

Part 4

Part 5

Part 6

Figures in this module

Readings (to be read before lectures 4-6)

Beadle & Tatum

Session 2

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Part 7 - Quantitative analysis of transformation

Figures in this module

Readings (to be read before lectures 4-6)

Avery Questions

Session 3

Part 1

Part 2

Part 3

Part 4

Figures in this module

Readings: Read the papers before watching Part 3 & Part 4

Origin of mutations

Session 4

Part 1

Part 2

Part 3

Part 4

Part 5

Figures in this module

Read the papers before watching parts 3 to 5

DNA structure and the fidelity of replication

Session 5

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Figures in this module

Read the 1961 topography paper before watching parts 5 & 6

Topography and gene fine structure

Session 6

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Part 7

Figures in this module

Read the Champe & Benzer paper before watching Part 2

Read the Crick paper before watching parts 5 to 7

Sequence of the end of rIIA and the beginning of rIIB

The genetic code

Session 7

Part 1

Part 2

Part 3

Part 4

Part 5

Figures in this module

Read the Champe & Benzer paper before watching part 2

Read the Brenner paper before watching parts 3 to 5

Readings comment on the origin of amber suppressor strains

Nonsense mutations

Session 8

Part 1

Part 2

Part 3

Part 4

Figures in this module

Read the Epstein paper before watching part 2

Read the Edgar & Wood paper before watching parts 3 & 4

T4 conditional mutants and phage assembly

Session 9

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Figures in this module

Read the Tatum and Lederberg paper before watching parts 2 to 4

Read the Wollman & Jacob paper before watching part 5

Read the review by Wollman et al. before watching part 6

Readings

Recombination and Hfr matings

Session 10

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Part 7

Figures in this module

Read the Pardee et al paper before watching part 5

Read the Jacob et al short paper before watching part 6

Read the Jacob and Monod review before watching part 7

Readings

The lactose operon

Session 11

Part 1

Part 2

Part 3

Part 4

Figures in this module

Read the Bertani 1951 paper before watching part 3

Read the Eisen 1971 paper before watching part 4

Readings

The cro gene of phage lambda

Session 12

Part 1

Part 2

Part 3

Part 4

Part 5

Part 6

Figures in this module

Read the Engelsberg et al. paper before watching parts 4 to 6

Readings

The arabinose system and positive control

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