Evidence-based Toxicology
- Offered byCoursera
- Public/Government Institute
Evidence-based Toxicology at Coursera Overview
Duration | 20 hours |
Total fee | Free |
Mode of learning | Online |
Difficulty level | Beginner |
Official Website | Explore Free Course  |
Credential | Certificate |
Evidence-based Toxicology at Coursera Highlights
- Shareable Certificate Earn a Certificate upon completion
- 100% online Start instantly and learn at your own schedule.
- Flexible deadlines Reset deadlines in accordance to your schedule.
- Beginner Level
- Approx. 20 hours to complete
- English Subtitles: French, Portuguese (European), Russian, English, Spanish
Evidence-based Toxicology at Coursera Course details
- Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
- The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
- Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies.
- This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.
Evidence-based Toxicology at Coursera Curriculum
Introduction & Shortcomings of Current Approaches
Welcome
Introduction to the Course
Introduction
Shortcoming No. 1: Narrative Reviews
Shortcoming No. 2: Bias in Reviews
Shortcoming No. 3: Evidence Writing
Shortcoming No. 4: External Validity
Shortcoming No. 5: Assessing New Methods
Shortcoming No. 6: Inadequate Reporting
Letter to Learners
Course Learning Objectives
Supporting reading
Practice Quiz 1
History and Causation
Welcome to Module 2
Personal First Exposures to Evidence-Based Medicine
The Start of EBT
The First Conference 2007 to the Start of the EBT Collaboration 2011
The Evidence-Based Toxicology Collaboration (EBTC)
Introduction Causation vs. Correlation
The Hill Principles of Epidemiology and their Relation to Toxicology
The Problem of Causation in Toxicology
Biomarker Concept in Mechanistic Toxicology
Mechanistic Validation
The Future of Causation in Complex Systems
Supporting reading
Supporting reading
Practice Quiz 2
Systematic Review and Meta-Analysis
Welcome to Module 3
Systematic Reviews: Definition and Principles
Systematic Reviews - Protocol Development
Systematic Reviews - Protocol Development (Part 2)
History
Meta-analysis Guidelines
Meta-analysis Protocol, Part 1
Meta-analysis Protocol, Part 2
Supporting reading
Supporting reading
Practice Quiz 3
Mid-course exam
Risk of Bias & Application to Test Methods Comparison
Welcome to Module 4
Introduction to Risk of Bias Concept in Critical Appraisal of Studies
Examples for Risk of Bias Tools 1: Cochrane Collboration
Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool
Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT
Quality Assessment in Evidence-Based Toxicology
Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)
Zebrafish Systematic Review
Supporting reading
Supporting reading
Practice Quiz 4
Quality Assurance, Good Practices, and Validation
Welcome to Module 5
The Concepts of Quality Assurance (QA) and Good Practice (GP)
Good Practice
Quality Assurance
Importance of GP and QA in EBT
The Evolution of Validation of Alternative Methods
The Traditional Validation Process
Example of a Validation Study: Skin Irritation
Developments in the Validation Area
Validation and Tox-21c/EBT
Supporting reading
Supporting reading
Practice Quiz 5
Biometrical Tools & Future Perspectives
Welcome to Module 6
Why We Need Biometry/Statistics in Evidence-Based Toxicology
Statistics and Bioinformatics Applied in Evidence-Based Approaches I
Statistics and Bioinformatics Applied in Evidence-Based Approaches II
Risk and Bias and Its Impact on Evidence-Based Approaches
Evidence-Based Is a More Rigorous Scientific Approach to Anything
The Reproducibility Crisis in Science
Where Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?
Supporting reading
Practice quiz 6
Final exam
Summative Assessment - Systematic Review Assignment
Systematic Review Assignment Instructions
Systematic Review Assignment Results
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