Introduction to Systems Biology
- Offered byCoursera
- Public/Government Institute
Introduction to Systems Biology at Coursera Overview
Duration | 19 hours |
Total fee | Free |
Mode of learning | Online |
Official Website | Explore Free Course  |
Credential | Certificate |
Introduction to Systems Biology at Coursera Highlights
- 30% started a new career after completing these courses.
- Earn a shareable certificate upon completion.
- Flexible deadlines according to your schedule.
Introduction to Systems Biology at Coursera Course details
- This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?
- The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate ?how? cell- level functions arise and ?why? mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.
Introduction to Systems Biology at Coursera Curriculum
Systems Level Reasoning
Molecules to Pathways
Overview of Systems Level Reasoning & Molecules to Pathways
Systems Level Reasoning I
Systems Level Reasoning II
Molecules to Pathways - cAMP and G Protein Pathways I
Molecules to Pathways - cAMP and G Protein Pathways II
Required Reading List
Lecture Slides
Lecture Slides
Systems Level Reasoning
Molecules to Pathways
Pathways to Networks
Physical Forces and Electrical Activity in Cell Biology
Pathways to Networks - MAP-kinase Pathways/Network I
Pathways to Networks - MAP-kinase Pathways/Network II
Mechanical Forces in Cell Biology
Electrical Activity in Cell Biology
Lecture Slides
Lecture Slides
Lecture Slides
Pathways to Networks
Physical Forces and Electrical Activity in Cell Biology
Mathematical Representations of Cell Biological Systems
Simulations of Cell Biological Systems
Mathematical Representations of Cell Biological Systems I
Mathematical Representations of Cell Biological Systems II
Simulations of Cell Biological Systems I
Simulations of Cell Biological Systems II
Lecture Slides
Lecture Slides
Lecture Slides
Mathematical Representations of Cell Biological Systems
Simulations of Cell Biological Systems
Experimental Technologies
Network Building and Analysis
Experimental Technologies
Analyzing Large Data Sets
Network Building/Analysis and Data Organization
Building Networks
Lecture Slides
Lecture Slides
Lecture Slides
Lecture Slides
Experimental Technologies
Network Building and Analysis
Midterm
Midterm Exam
Analysis of Networks
Topology to Function
Analysis of Networks I
Analysis of Networks II
From Topology to Function: Directed Sign Specified Graphs I
From Topology to Function: Directed Sign Specified Graphs II
Lecture Slides
Lecture Slides
Lecture Slides
Analysis of Networks
Topology to Function
Strengths and Limitations of Different Types of Models
Identifying Emergent Properties
Strengths and Limitations of Different Types of Models I
Strengths and Limitations of Different Types of Models II
Identifying Emergent Properties: Bistability I
Identifying Emergent Properties: Bistability II
Lecture Slides
Lecture Slides
Lecture Slides
Lecture Slides
Strengths and Limitations of Different Types of Models
Identifying Emergent Properties
Emergent Properties: Ultrasensitivity and Robustness
Case Studies
Ultrasensitivity
Robustness and Scaffolds
Case Studies I
Case Studies II
Lecture Slides
Lecture Slides
Lecture Slides
Lecture Slides
Emergent Properties: Ultrasensitivity and Robustness
Case Studies
Case Studies
Systems Biomedicine
Systems Pharmacology and Therapeutics
Perspective
Case Studies III
Case Studies IV
Systems Biomedicine
Systems Pharmacology and Therapeutics
Perspective
Lecture Slides
Lecture Slides
Lecture Slides
Lecture Slides
Case Studies
Systems Biomedicine
Systems Pharmacology and Therapeutics
Perspective
Final
Final Exam
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