Circadian clocks: how rhythms structure life 

1.0 Introduction to the First Half of Lecture 1

1.1 The Family of Biological Rhythms

1.2 The Circa-Rhythms

1.3 Spatial and Temporal Niches

1.4 The Case of Gonyaulax polyedra

1.5 Introduction to the Second Half of Lecture 1

1.6 Circadian Rhythms in Mammals

1.7 Circadian Clocks in Flies, Plants and Fungi

1.8 Wrap up for Lecture 1

Literature suggestion

Lecture 1, Introduction, first half.

Lecture 1, Introduction, second half.

2.0. Introduction to Lecture 2

2.1 Pittendrigh´s generalisations 1-9

2.2 Pittendrigh´s generalisations 10 and 11

2.3 Pittendrigh´s generalisations 12-16 and entrainment

2.4 Wrap-up for Lecture 2

Literature suggestion

Translation of de Mairan's botanical observation

Obituary Jürgen Aschoff

Formalisms

3.0 Introduction to Lecture 3

3.1 The first clock gene

3.2 The negative feedback hypothesis

3.3 More clock genes -many more!

3.4 Post transcriptional mechanisms and the clock

3.5 Indications of a non-transcriptional clock

3.6 Zeitgebers and the molecular clockwork

3.7 Wrap-up to Lecture 3

Literature suggestion

Lecture 3 Molecular mechanisms

4.0 Introduction to Lecture 4

4.1 Clock control: which processes in humans and how to measure them?

4.2 Schwänzeltanz

4.3 The SCN regulates the timing of physiology and behaviour

4.4 Clock controlled genes (ccg´s)

4.5 Clock regulation of behaviour: genetic mechanisms

4.6 Clock regulation of other major regulatory systems

4.7 Wrap-Up to Lecture 4

Literature suggestion

Lecture 4: Clock control

5.0 Introduction to Lecture 5

5.1 Chronotypes

5.2 What makes up Chronotypes?

5.3 Linking chronotype and light entrainment

5.4 How modern life styles affect sleep

5.5 Wrap-up to Lecture 5

The link to the MCTQ

Human

6.0 Introduction to the First Half of Lecture 6

6.1 What is normal and what not and why?

6.2 The consequences of living against the clock

6.3 Circadian changes and Pathologies - comorbidities or causal factors

6.4 Introduction to the Second Half of Lecture 6

6.5 Clock genes that can really mess up the timing of sleep

6.6 The clock gene mutant mice are sick

6.7 Chronopharmacology and chronochemotherapy

6.8 The circadian clock is a fitness characteristic

6.9 Wrap-up to Lecture 6

6.10 Farewell from your CircaClock Team

Final Exam "Circaclock"

Pathology

Lecture 6. Clock and pathologies