USMLE Exam: Guide for Medical Students
clickHere

USMLE Exam: Guide for Medical Students

14 mins read554 Views Comment
Talk to Expert Icon BlueTalk to Expert
clickHere
Raushan
Raushan Kumar
Assistant Manager Content
Updated on Nov 13, 2025 15:57 IST

Want to become a doctor in USA and practice medicine there? Then you will have to take USMLE exam. In this guide, we explain steps, fees and how to apply for the USMLE. USMLE or United States Medical Licensing Examination is for those wanting a license as physicians in USA.

USMLE Exam

 USMLE test checks knowledge and skills before allowing them to work as doctors. The USMLE assesses medical knowledge, clinical concepts and patient centered skills. The USMLE exam is tested in three steps - Step 1 is for basic medical knowledge, Step 2 is Clinical Knowledge and Step 3 tests if you can apply medical knowledge in real life situations. This exam is not easy to crack and needs preparation. Many international medical graduates (IMGs) take USMLE to get a chance to work in the USA. Doing well in the exam helps in getting a residency in the USA, which is a big step toward becoming a doctor there. After clearing USMLE Step 1 and Step 2, the next step is getting into residency. Learn more about how to get medical residency in US.

Table of content
  • USMLE Exam: Key Highlights
  • USMLE Full Form
  • What is USMLE Exam?
  • USMLE Exam Dates 2025
  • USMLE Eligibility for Indian Students
  • USMLE Application Process
  • How to Apply for USMLE from India
  • Some Important Things
  • USMLE Exam Fees in India 2025
  • USMLE Exam Centre 2025
  • USMLE Exam Pattern
  • USMLE Exam Syllabus
View More

USMLE Exam: Key Highlights

Feature

Details

Full Form

United States Medical Licensing Examination

Short Form

USMLE

Conducting Body

The Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME)

Exam Type

Licensing Examination for Medical Graduates

Exam Level

International

Purpose

To assess a physician's ability to apply knowledge and skills for safe and effective patient care

Exam Format

3 Steps

  • Step 1: Tests basic medical sciences
  • Step 2 CK: Assesses clinical knowledge
  • Step 3: The ability to apply medical skills in unsupervised practice

Exam Mode

Computer-based

Accepted In

United States

Exam Duration

Step 1:8 Hours

Step 2 CK: 9 Hours

Step 3: 2 days

Mode of Application

Online

Language

English

Official Website

www.usmle.org

Other Medical Exams: 

MCAT Exam

PLAB Exam for UK

DHA Exam for Dubai 

USMLE Full Form 

USMLE full form is United States Medical Licensing Examination. The test is owned by two by the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). It is one of the toughest exams in the world. If you are exploring higher education in the medical field post-MBBS, consider the Masters of Medicine & Health Sciences in USA.

What is USMLE Exam? 

The USMLE is part of licensed medical practice in USA. The exam includes a three step assessment process: USMLE Step 1, Step 2 and Step 3. Those who pass each sub exam in USMLE can become medical practitioners in USA with license.

Score Predictor

Predict your IELTS, TOEFL, and PTE in just 4 steps!

Share 12th Board, Percentage, english score
Get estimated scores or IELTS, TOEFL & PTE


USMLE Step 1

Test includes 280 MCQs divided into seven 60 minute blocks. This test is eight hours long.







USMLE Step 2

Assesses ability to apply medical knowledge, clinical skills and understanding clinical science concepts. The test includes 318 MCQs divided into eight 60 minute blocks. The test is nine hours long.

USMLE Step 3

Assesses ability to apply medical knowledge and understanding of biomedical and clinical sciences in real life cases of medicine.

Step 3 exam is spread over two days:

  • Day 1 – Foundations of Independent Practice (FIP): Tests 232 MCQs in six 60 minute blocks.
  • Day 2 – Advanced Clinical Medicine (ACM): Tests on 180 MCQs in six 45 minute blocks with 13 computer-based case simulations (CCS), each lasting for about 10 to 20 minutes

USMLE Exam Dates 2025 

The USMLE exam has no fixed dates. The USMLE test dates 2025 are available year-round. Candidates choose a three-month eligibility period during registration and can schedule their exam on any available date within that window.

Step 1 and Step 2 CK can be taken at Prometric centers in India and abroad, based on slot availability. Students usually take Step 1 after the second year of MBBS, and Step 2 CK after clinical rotations or the final year.

Step 3 must be taken only in the US and spans two consecutive days. It is available only to those who have cleared Step 1 and Step 2 CK and received ECFMG certification.

Popular months like May-August and November-January fill up quickly, so it is best to book at least 6–8 weeks in advance. Always use the Prometric website with the scheduling permit to check and secure a preferred slot.

USMLE Eligibility for Indian Students

Medical aspirants who are planning to take the USMLE test must fulfill the eligibility requirements to apply for the test. The USMLE test eligibility for Step 1, Step 2 CK, and Step 3 is as follows:

USMLE Step 1 and Step 2 CK Eligibility

  • Medical students or graduates from a US or Canadian MD program accredited by the LCME are eligible to apply for USMLE Step 1 and Step 2 CK.
  • Candidates or graduates who have a US DO program accredited by COCA.
  • A student or graduate from an international medical school listed in the World Directory of Medical Schools and meeting ECFMG eligibility requirements can apply for the USMLE.

USMLE Step 3 Eligibility

  • Candidates need to achieve passing scores on Step 1 and Step 2 CK.
  • Candidates must fulfill all the eligibility criteria as listed in the USMLE Bulletin of Information.
  • Candidates must have an MD or DO degree from a US or Canadian medical school accredited by LCME or COCA, OR an equivalent MD degree from an international medical school listed in the World Directory of Medical Schools, and must also obtain ECFMG Certification.

Before applying for USMLE understand MD in USA because there is no MBBS in USA.

USMLE Application Process

Check out separate application processes for USMLE

USMLE Step(s)

Who Can Apply

Where to Apply

Step 1, Step 2 CK, Step 2 CS

Students/graduates of LCME or AOA-accredited US/Canada med schools

NBME on NLES (NBME Licensing Exam Services)

Step 1, Step 2 CK, Step 2 CS

Students/graduates of international medical schools

ECFMG on IWA (Interactive Web Applications)

Step 3

Graduates who passed Step 1, Step 2 CK, and Step 2 CS

FSMB (Federation of State Medical Boards)

How to Apply for USMLE from India

 

If you are an MBBS student in India and want medical residency in USA you have to appear for USMLE from India. Follow how can you register for USMLE from India.

Get Your USMLE or ECFMG ID

  • First, go to the ECFMG website.
  • Click on “I want to apply for ECFMG Certification.”
  • Fill in your details like full name, email, date of birth, etc.
  • After 4 to 5 working days, you'll get your USMLE or ECFMG ID and password on email.
  • This ID is very important. You will need it for other exams also.

Login on IWA Portal

  • Now go to the IWA (Interactive Web Applications) login page.
  • Use your ECFMG ID and password to login.
  • Fill the form carefully. Name, DOB, and passport details should match.
  • If anything is wrong, it can delay your process badly.

Apply for ECFMG Certification

  • Once you're logged in, click on "Apply for ECFMG Certification".
  • Fill application and pay USD 160.
  • After this, complete Form 186, which is an identity form.
  • This is filed through video call using NotaryCam.

Apply for USMLE Step 1 or Step 2

  • When ECFMG cert is accepted, go back to IWA and click on "Begin New Application".
  • Select the exam - Step 1 or Step 2 CK.
  • Choose your eligibility period when you want to give the exam.
  • Select India as your exam location.
  • Pay the exam fees Step 1 is USD 1215 total. That's around INR 1 Lakh to INR 1.05 lakh in Indian rupees.

Send Form 183 from Your College

  • After payment, you will get access to Form 183.
  • Download and take it to your Dean's office. They must sign, stamp, and seal it in a college envelope.
  • Then courier it to ECFMG office in the USA 

IWA – ECFMG  

3624 Market Street,  

Philadelphia, PA 19104-2685, USA

Wait for the Scheduling Permit

  • After sending Form 183, wait 2 to 3 weeks.
  • Once ECFMG approves, they'll send you a scheduling permit on email.
  • This permit is used to book your test date.

Book Your Exam Date on Prometric

  • Go to Prometric.com, search for USMLE exam.
  • Click your exam (Step 1 or Step 2), and select Indian exam center.
  • Enter your details and use the scheduling permit to book the date.
  • You must take the test in within 3 month window you selected.

Some Important Things

  • Keep your passport ready – not expired.
  • Make sure all names and details match exactly in all forms.
  • If you miss your 3-month slot, you’ll have to pay and apply again.
  • You can reschedule your test date, but extra fee may apply.

USMLE Exam Fees in India 2025

USMLE Process / Item

USMLE Fee (USD)

USMLE Fee (INR)

Application for ECFMG Certification

USD 160

INR 13,841.60

USMLE Step 1

USD 1020 - Examination Fee + International Test Delivery Surcharge, if testing outside the United States and Canada

INR 88,237.20

USMLE Step 2 CK

USD 1020 - Examination Fee + International Test Delivery Surcharge, if testing outside the United States and Canada

INR 88,237.20

USMLE Step 3

USD 935 

INR 80,878

Extension of Eligibility Period (Step 1/Step 2 CK)

USD 100 per exam

INR 8,651.00

Testing Region Change (Step 1/Step 2 CK)

USD 90 per change

INR 7,785.90

USMLE Rescheduling Fee (Step 1/Step 2 CK)

Varies (can be USD 0)

INR 0 or more

USMLE Score Recheck (Step 1/Step 2 CK)

USD 80 per exam

INR 6,920.80

USMLE Exam Centre 2025

The USMLE exam is held at Prometric test centres in the US and some other countries. International students can take Step 1 and Step 2 CK at approved centres outside the US. But Step 3 must be taken only in the United States, as it is the final step for getting a medical license.

USMLE Exam Centre in India

A total of 9 USMLE exam centres are available in India. These test centres are located in major cities like Chennai, Hyderabad, Ahmedabad, Bangalore, Kolkata, Allahabad, Mumbai, and New Delhi.

City

Test Centre Name

Address

Chennai

Prometric Testing Pvt. Ltd.

No - 15/7, 2nd Floor, Jagannathan Road, Nungambakkam, Chennai 600034

Contact: 044-2824 1840

Hyderabad

Prometric Testing Pvt. Ltd.

Avenue 1, Street 20, Plot 1672, Road 12, Banjara Hills, Hyderabad 500034

Contact: 040-2330 3903

Ahmedabad

Prometric Testing Pvt. Ltd.

301-302 Abhijeet II, Mithakhali Six Roads, Ellisbridge, Ahmedabad 380006

Contact: 079-2656 1088

Bangalore

Prometric Testing Pvt. Ltd.

Maini Sadan, 1st Floor, No. 38, Lavelle Road, 7th Cross Rd, Bangalore 560001

Contact: 080-2229 1770

Kolkata

Prometric Testing Pvt. Ltd.

Flat 1/C, Sukh Sagar Bldg, 2/5 Sarat Bose Road, Kolkata 700020

Contact: 033-2485 2792

Allahabad

Institute of Psychological & Educational Measurement

119/25-A, Mahatma Gandhi Marg, Civil Lines, Allahabad 211001

Contact: 0532-2427048

Mumbai

Prometric Testing Pvt. Ltd.

Marwah House, Saki Vihar Road, Sakinaka, Andheri (E), Mumbai 400072

Contact: 022-2857 3160

Mumbai

United States Education Foundation in India

4 - New Marine Lines, Mumbai 400020

Contact: 022-2262 4603

New Delhi

Prometric Testing Pvt. Ltd.

2nd Floor, DLF Infinity Tower-A, Gurgaon 122002

Contact: 0124-4147700

USMLE Exam Pattern

Step 1 and Step 2 are administered at Prometric centers worldwide, while Step 3 is taken in the USA. Understand USMLE paper pattern

USMLE Step 1 Exam Pattern

Step 1 consists of MCQs around interpreting images, graphs, or tables created by expert committees of doctors, educators, and researchers from US organized by organ systems and foundational sciences.

USMLE Step 1 Test Section Weightage

System

Range %

Human Development

1-3

Blood & Lymphoreticular/Immune Systems

9-13

Behavioral Health & Nervous Systems/Special Senses

10–14

Musculoskeletal, Skin & Subcutaneous Tissue

8-12

Cardiovascular System

7-11

Respiratory & Renal/Urinary Systems

11-15

Gastrointestinal System

6-10

Reproductive & Endocrine Systems

12–16

Multisystem Processes & Disorders

8-12

Biostatistics & Epidemiology/Population Health

4–6

Social Sciences: Communication and Interpersonal Skills

6–9

USMLE Step 2 CK Exam Pattern

USMLE Step 2 is a one day long exam. with MCQs testing Sequential case Questions Scientific abstracts Items with audio or video findings

  • Standard MCQs
  • Sequential case questions
  • Scientific abstracts 
  • Items with audio or video findings

USMLE Step 2 Test Section Weightage

System

Range, %

Human Development

2–4

Immune System

3–5

Blood & Lymphoreticular System

3–6

Behavioral Health

5–10

Nervous System & Special Senses

5–10

Musculoskeletal System/Skin & Subcutaneous Tissue

6–12

Cardiovascular System

6–12

Respiratory System

5–10

Gastrointestinal System

5–10

Renal & Urinary System & Reproductive Systems

7–13

Pregnancy, Childbirth & the Puerperium

3–7

Endocrine System

3–7

Multisystem Processes & Disorders

4–8

Biostatistics & Epidemiology/Population Health/Interpretation of Medical Literature

3–5

Social Sciences: Legal/Ethical Issues & Professionalism/Systems-based Practice & Patient Safety

10-15

USMLE Step 3 Paper Pattern 

Step 3 is the final exam in the USMLE series that assesses whether a candidate is ready to practice medicine without supervision. Step 3 content mirrors the types of clinical challenges seen in actual practice. Questions are based on 18 major content areas and include a broad mix of patient demographics (age, gender, culture, occupation). 

USMLE Step 3 Test Section Weightage

System

Range, %

Human Development

1–3

Immune System, Blood & Lymphoreticular System, and Multisystem Processes/Disorders

6–8

Behavioral Health

4–6

Nervous System & Special Senses

8–10

Skin & Subcutaneous Tissue

4–6

Musculoskeletal System

5–7

Cardiovascular System

9–11

Respiratory System

8–10

Gastrointestinal System

6–8

Renal/Urinary & Male Reproductive Systems

4–6

Pregnancy/Childbirth & Female Reproductive System & Breast

7–9

Endocrine System

5–7

Biostatistics & Epidemiology/Population Health & Interpretation of the Medical Literature

11–13

Social Sciences: Communication Skills/Ethics/Patient Safety

7–9

USMLE Exam Syllabus 

Here is a brief USMLE syllabus with main topics and sub topics:

System/Area

Key Topics

1. General Principles of Foundational Science

Biochemistry: Gene expression, protein synthesis, enzymes, energy metabolism.
Cell Biology: Cell cycle, apoptosis, cancer biology.
Human Genetics: Inheritance patterns, pedigree analysis, gene therapy.
Tissue Responses: Inflammation, healing, fibrosis.
Pharmacology: Pharmacokinetics, drug actions/interactions.
Microbiology: Bacteria, viruses, fungi, parasites, prions.

2. Immune System

Immune Cells: T cells, B cells, NK cells, APCs.
Immune Response: Antigen processing, MHC I/II, cytokines, complement system.
Disorders: Immunodeficiencies, hypersensitivity types, transplant rejection.
Diagnostics & Vaccines: ELISA, immunoglobulins, vaccine actions.

3. Blood & Lymphoreticular System

Hematology: RBC, WBC, platelet production, coagulation.
Disorders: Anemias, leukemias, lymphomas, bleeding/clotting disorders.
Infections: Lymphadenitis, viral hemorrhagic fevers, malaria.
Drug Effects: Anticoagulants, chemotherapy, transfusion reactions.

4. Behavioral Health

Normal: Coping, adherence, stress responses.
Psychiatric Disorders: Psychotic, mood, anxiety, personality, childhood disorders.
Substance Use: Alcohol, opioids, cannabis, stimulants.
Psychosocial Issues: Grief, adjustment, sexual/gender identity.

5. Nervous System & Special Senses

Neuroanatomy: Brain, spinal cord, cranial nerves.
Sensory & Motor Systems: Vision, hearing, balance, proprioception.
CNS Biology: Neurons, glia, neurotransmitters.
Disorders: Meningitis, encephalitis, neurodegeneration.

6. Skin & Subcutaneous Tissue

Normal Processes: Embryonic & neonatal development; Structure, barrier & thermal regulation; Eccrine function & repair across lifespan.
Infectious Disorders: Bacterial (Impetigo, cellulitis, anthrax, MRSA); Viral (Herpes simplex, zoster, measles); Fungal (Dermatophytosis, candidiasis); Parasitic (Scabies, cutaneous larva migrans).
Inflammatory & Autoimmune Disorders: Psoriasis, dermatitis, pemphigus, erythema multiforme.
Neoplasms: Benign (Nevi, lipoma); Malignant (Melanoma, BCC, SCC).
Other Disorders: Hair/nail/sweat gland disorders; Oral lesions; Drug reactions.

7. Musculoskeletal System

Normal Processes: Organ & cell structure of bones, joints, muscles; Exercise physiology.
Infectious Disorders: Osteomyelitis, discitis, septic arthritis.
Autoimmune/Inflammatory: Rheumatoid arthritis, spondyloarthritis, myositis.
Degenerative/Metabolic: Osteoarthritis, osteoporosis, gout, rhabdomyolysis.
Neoplasms: Osteosarcoma, ganglion cysts, bone metastases.
Trauma & Congenital: Fractures, dislocations, scoliosis, Osgood-Schlatter.
Drug Effects: Statin-induced myopathy, steroid effects.

8. Cardiovascular System

Normal Physiology: Heart structure, conduction, circulation, regulation; ANP secretion, vascular resistance.
Infectious/Inflammatory: Myocarditis, bacterial endocarditis.
Arrhythmias: A-fib, V-tach, torsades, bradycardia, AV blocks.
Vascular Disorders: Aneurysms, thrombosis, varicose veins.
Hypertension & Dyslipidemia: Essential/secondary HTN, hyperlipidemia.
Neoplasms: Cardiac myxomas, metastatic tumors.
Congenital Defects: ASD, VSD, Tetralogy of Fallot.
Drug-Induced: Effects from adriamycin, cocaine, CCBs.

9. Respiratory System

Normal Anatomy & Physiology: Airways, gas exchange, surfactant, ventilation; Defense mechanisms and flora.
Infectious Disorders: URI, pneumonia (bacterial, viral, fungal); TB, bronchitis, sinusitis.
Obstructive & Restrictive Diseases: Asthma, COPD, interstitial lung diseases.
Neoplasms: Lung cancer types, mesothelioma, nasal polyps.
Vascular & Structural Disorders: Pulmonary embolism, edema, ARDS.
Congenital & Drug-Induced Issues: Diaphragmatic hernia, oxygen toxicity.

10. Gastrointestinal System

Normal Physiology: GI anatomy, motility, hormones, absorption; Liver, pancreas, salivary glands.
Infectious Disorders: C. difficile, E. coli, hepatitis A–E, parasites.
Autoimmune/Inflammatory: Celiac, IBD (Crohn’s, ulcerative colitis).
Neoplasms: Oral, esophageal, gastric, colorectal cancers.
Disorders by Region: GERD, ulcers, IBS, appendicitis, hemorrhoids.
Liver: Cirrhosis, hepatitis, portal hypertension.
Pancreas: Pancreatitis, cysts, insufficiency.
Congenital & Drug-Induced: Pyloric stenosis, Meckel’s diverticulum; NSAID ulcers, acetaminophen hepatitis.

11. Renal & Urinary System

Normal Processes: Embryonic development; Kidney structure/function, acid-base balance; Hormones (renin, aldosterone, vasopressin); Micturition.
Abnormal Processes: Infections (pyelonephritis, cystitis); Immunologic disorders (IgA nephropathy, lupus nephritis); Neoplasms (Wilms' tumor, renal cell carcinoma); Renal failure (AKI, CKD); Calculi; Congenital anomalies; Drug effects.

12. Pregnancy, Childbirth & the Puerperium

Normal Processes: Fertilization, implantation, embryonic development; Labor and delivery; Lactation.
Abnormal Processes: Prenatal care/screenings; Obstetric complications (ectopic pregnancy, preeclampsia); Labor complications (shoulder dystocia); Puerperal issues (postpartum hemorrhage); Neonatal disorders (SIDS, RDS); Drug effects (teratogens).

13. Female Reproductive System & Breast

Normal Processes: Ovulation, menstrual cycle, puberty; Breast development.
Abnormal Processes: Infections (PID, vaginitis, STIs); Neoplasms (cervical, ovarian, endometrial); Menstrual disorders (amenorrhea, PCOS); Fertility (ART); Menopause; Sexual dysfunction; Drug effects.

14. Male Reproductive System

Normal Processes: Spermatogenesis, puberty; Genital and prostate function.
Abnormal Processes: Infections (prostatitis, STIs); Neoplasms (testicular and prostate cancer); Sexual dysfunction (ED); Congenital disorders (hypospadias); Drug effects.

15. Endocrine System

Normal Processes: Structure and hormones of pituitary, thyroid, adrenal, pancreas; Hormone synthesis.
Abnormal Processes: Diabetes mellitus (types 1, 2); Thyroid disorders (hypo/hyperthyroidism, cancer); Adrenal disorders (Addison's, Cushing’s); Pituitary disorders (prolactinoma); Congenital/endocrine neoplasia (MEN syndromes).

16. Multisystem Processes & Disorders

Normal Processes: Nutrition and metabolism; Electrolyte/water balance; Intracellular storage disorders.
Abnormal Processes: Infections (Lyme, TB, rickettsial diseases); Inflammatory (SLE, vasculitis); Paraneoplastic syndromes; Amyloidosis; Environmental exposure.

17. Biostatistics, Epidemiology/Population Health & Medical Literature

Study design and selection; Screening principles; Diagnostic test evaluation; Error types and bias; Statistical measures (sensitivity, specificity); Epidemiologic measures (incidence, prevalence); Critical appraisal of clinical studies; Risk assessment.

18. Social Sciences

Medical ethics and jurisprudence; Consent, confidentiality, advance directives; Cultural competence and health disparities; Public health systems; Health economics; Patient safety and quality; Communication and teamwork.

Thinking about long-term goals? Here's what you can expect to earn after residency. Check the average doctor salary in USA.

Q:   Is USMLE harder than NEET?
A:

Yes, many students say that USMLE is harder than NEET, especially for Indian students. NEET mostly checks your memory and basic understanding. But USMLE is more about concepts, clinical thinking, and applying knowledge in real-life patient cases. Also, it is in English, and the question style is different. So, yes, it feels more tough, but it's not impossible.

Q:   Can I give USMLE after MBBS?
A:

Yes, you can give USMLE after MBBS. In fact, many students start preparing for it during MBBS or internship. Once you finish MBBS from a recognised medical college, you can apply for the exam. So yes, after MBBS is a good time to give USMLE if you want to go to the USA for PG.

Q:   Is USMLE valid in India?
A:

USMLE is not valid in India to directly practice as a doctor. Even if you pass USMLE, you cannot work in India unless you also clear NEXT or other Indian medical exams. But if you finish your residency in the USA, you can come back and work in India after registering with the NMC (National Medical Commission). So USMLE is for the USA, not a replacement for NEET PG or FMGE in India.

About the Author
author-image
Written by
Raushan Kumar
Assistant Manager Content
Raushan Kumar is a skilled writer and a Study Abroad Expert in the Editorial Team at Shiksha. He oversees various aspects of studying abroad, including educational opportunities, entrance exams, colleges, latest new Read Full Bio
Explore popular study destinations
Resources for you
Understand the process step by step by referring to these guides curated just for you
qna

Comments