CBSE 12th

Hello Tisha,
No, class 6th subject or optional subject won't make a difference.
*It depends on the college too, if you are applying for a course which is based on an entrance test then optional subject won't matter at all.
*Merit based Bachelor's courses are less in India. Terms of each college vary here too. For example, most of the courses of DU are merit-based, but you can't include the marks of 6th subject in the 'Best Four Subjects' (BFS) just like that. Terms vary from course to course. You may face deduction of 2-3% from your BFS% if you include your class 6th subject.
#Above all, It doesn't really matters. You are allotted the 6th subject by your school just so that your overall percentage increases and so does their own reputation.
#Overall percentage also is not important you see Tisha, why? (1) It won't matter if you are giving an entrance test (2) It may or may not matter in DU because BFS% is considered and some % is deducted upon including 6th subject (3) Policies of other merit-based colleges vary and little can be said about them. For example, Fergusson Pune checks just your class 12th mark sheet and then releases merit lists without you even knowing how they selected or rejected students. Hence, you can't say if they checked your optional subject's marks or not.

NID offers Bachelor of Design B. Des course at NID-Ahmedabad, as well graduate Diploma Programme in Design (GDPD) course at NID Vijayawada and NID Kurukshetra. The GDPD course is of four year duration. Candidates can view below NID Entrance Exam 2019 eligibility criteria for B. Des & GDPD course admissions. The eligibility criteria for NID Entrance Exam for B.Des/GDPD course admissions states that candidates who have cleared or who will be appearing for their higher secondary (10+2) qualifying examination from any stream (Science, Arts, Commerce, etc. ). From any recognized board such as CBSE, IB, ICSE or their equivalent in the year 2017-2019 can apply for the exam.

Hello,
It Is clear that you are in typical Shakespearen dilemma. You have obtained very good marks in class 12th. These marks will get you admission in any college in any branch in the country. But, which branch to take is the dilemma that many students like you are facing. All these days the typical branches or the streams that were chosen by the students were medical or engineering. However Engineering has reached saturation mark and for medical it's quite tough to get it. I would advise you to ponder, wait, meditate, discuss with your parents and have a look as to which subject or which stream you like the most or which one you fascinate the most. It's high time you selected the right path which you like and not the ones which are being chosen by many other students simply because these are chosen by others. Best wishes to you.