CBSE

The eligibility criteria of B.Tech Biotechnology of Shobhit Institute of Engineering and Technology Meerut is given below.
Eligibility Criteria : 10+2 with minimum 5 subjects passed with minimum 50% marks. Physics and Biology/ Biotechnology as compulsory subjects.
Admission Procedure : Students with valid scores in JEE-Main / Any State Engineering Entrance Examination are eligible for Direct Admission. Students securing 70% in class XII (CBSE/ ICSE Boards) or 65% (in State Boards) 2018-19 examinations are also eligible for Direct Admission. 5% additional weightage is given to Girl candidates.
So from above if you have any entrance exam score like JEE Main, UPSEE etc can be eligible here for direct admission. However on the basis of your 12th CBSE marks you are not eligible here for direct admission. So use your entrance scores if have for admission.

Well, your friend scored well in 12th so congrats to him first. LPU NEST plays the role of eligibility and scholarship in courses LPU offers. As you have not mentioned programme name your friend is interested in so it's difficult to answer your query. LPU offers 200+ professional programmes and each programme eligibility and admission criteria are different. I suggest you to ask your friend to explore course details on LPU official website-https://www.lpu.in/
I also come to know admission session 2020 of LPU is ongoing and the last date to apply is 30th November so alert your friend to take a wise decision. For further queries, your friend can contact on LPU tollfree number as mentioned on LPU official website.