Science

Yes, you can do CPL, even if you have done class 12th form NIOS, provided you score 50% in PCM.
You need to understand that Pilot training is governed and regulated by DGCA and it is irrespective of the flying school you choose to train with.
For becoming a commercial pilot, there is a specific eligibility criteria, which you should first be aware of. This is decided on what subjects have you taken in class 12th. It requires PCM to be a pilot. And, even if you have not opted for the same, then you can appear separately for these subjects and become eligible. Further, you should be aware that you are medically fit to be a pilot, so I would suggest you to visithttp://www.dgca.nic.in/medical/medical-ind.htmandgototheclass2nd examiners tab to find out doctors who will examine you for initial fitness. You can visit any doctorate from the list as per your convenience. Once you are done with Class 2nd medical, find out a suitable flying club for you as per your convenience. You can fly in India or abroad. I would suggest you fly in India. Besides finding the club, be aware that you will have to appear for:
1. Air Navigation
2. Aviation Meteorology
3. Air Regulations
4. Aviation Technical
5. Aircraft Specific
6. Radio Telephony
Here, 1-5 are conducted by DGCA and 6 is conducted by WPC. Prepare for these subjects and appear, as exams are conducted every quarterly. For preparation, flying club will help you or there are private instructors available in metro cities as well. You will fly for 200Hrs + Clear DGCA and WPC exams + Clear Class 1st medical, then you shall get your CPL. The next license is ATPL, which you shall be able to apply for once. You will then have to probably fund or self-sponsor your type rating on whatever fleet you are selected in an airline. Then, you finally get a job as a pilot. I hope the process is well explained to you. CPL is an expensive affair. It might cost you around Rs.18-20 Lacs for flying + DGCA exams Rs.500/- each exam + Medicals for Rs.10, 000 + endorsements and license issue fees around Rs.25k + Type Rating around Rs.15 Lacs. So, decide wisely before you enter the field.