IIT Guwahati develop methods to analyse Ayurvedic therapy

The present study that used the emerging scientific approaches of Network Pharmacology and Chemoinformatics shows how the formulation is likely to work in the human body.

A team of researchers at the Indian Institute of Technology (IIT) Guwahati has developed a modern drug development method to analyze the mode of action of Ayurvedic rejuvenating medicine - Amalaki Rasayana. The study has found that Amalaki Rasayana reduces high blood pressure-induced structural and functional changes in the heart.

Earlier, studies reveal long-term oral intake of this rejuvenating medicine reduces the thickening of the heart muscle and improves heart function. The present study that used the emerging scientific approaches of Network Pharmacology and Chemoinformatics shows how the formulation is likely to work in the human body.
While speaking about the development, Professor Ramakrishnan, Professor, Department of Biosciences and Bioengineering, IIT Guwahati said, “The hallmark of Ayurvedic system is the long-standing unverified claim that it is a holistic approach; it treats the body as a whole.

Multiple components in ayurvedic medicine are believed to act synergistically to improve a diseased condition. Our analysis using the tools and techniques of modern medicine suggests that this is, indeed, true.” 
Network pharmacology analyses the influence of drugs on diseases as a whole and is effective for developing multi-component therapeutics, which is typical of a traditional system like Ayurvedic. The scientists employed in-vivo studies in small animals, gene-expression and proteomics analysis, informatics tools and the techniques of Systems Medicine, all of which are used in the development of allopathic drugs. They also examined the possible synergy among the actions of different components of the Rasayana using the Network Pharmacology approaches.
 “This interdisciplinary approach provides opportunities for systematic investigations for unravelling the mechanism of action of multicomponent Ayurvedic medicines from the perspective of a network of normal functional pathways as well as pathways that are altered in chronic diseases”, said Prof. Kartha, Academy of Cardiovascular Sciences.

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