The research team led by Prof. Ranjana Pathania discovered that the drug Disulfiram can prevent the normal functioning of Metallo--lactamase, an enzyme that neutralizes last resort carbapenem antibiotics.
IIT Roorkee researchers develop unique way to deal with blood infections
A team of researchers from the Indian Institute of Technology (IIT) Roorkee has come up with a novel mechanism of Disulfiram in treating blood infections and pneumonia caused by the Metallo-beta-lactamase producing Acinetobacter baumannii, a nosocomialtop priority pathogen.
The research team led by Prof. Ranjana Pathania discovered that the drug Disulfiram can prevent the normal functioning of Metallo--lactamase, an enzyme that neutralizes last resort carbapenem antibiotics. Disulfiram thus improves the antibacterial activity of Carbapenem class of antibiotics against carbapenem-resistant Acinetobacter baumannii.
The study by Vineet Dubey, Kuldip Devnath, Mangal Singh, Prof. Ranjana Pathania and others working in the Molecular Bacteriology and Chemical genetics laboratory in the Department of Biosciences and Bioengineering, IIT Roorkee, has been published by Oxford University Press in the Journal of Antimicrobial Chemotherapy.
Acinetobacter baumannii is a serious problem in hospitals worldwide. This is because it is one of the primary causes of infection in patients who rely on hospital ventilators and invasive devices like urinary catheters.
Around 63 per cent of infections are caused by the multidrug-resistant strains of this bacterium, which is of primary concern due to its increased resistance to antibiotics.
Since these pathogens have Carbapenem degrading enzymes, the World Health Organization (WHO) has designated this pathogen as a critical priority for research and development of new treatment drugs in 2017.
The institute is currently celebrating its 175th anniversary. The celebrations started on November 25, 2021 and will continue till November 24, 2022. Different academic, cultural, sports, outreach activities are being planned by students, faculty, staff and alumni during the year of celebrations, the institute said.
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